Acid ceramidase is a lysosomal enzyme required to break down ceramide into fatty acids and sphingosine. Mutations in this enzyme have been implicated in Farber disease, a lysosomal storage disorder.
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Glucosylceramide synthase (GCS) catalyzes the transfer of glucose from UDP-glucose to ceramide to form glucosylceramide, the precursor of most higher order glycosphingolipids.
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Phosphoserine aminotransferase is implicated in serine biosynthesis and is overexpressed in several cancer lines.
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The serine palmitoyltransferase (SPT) enzyme is involved in making certain fats called sphingolipids which are important components of cell membranes and play a role in many cell functions.
Dysfunction or low concentration of active SPT disrupts the formation of myelin, causing nerve cells to become less efficient at transmission of impulses and nerve cell death. This condition is called sensory neuropathy type 1.
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Please call (800) 383-7795 or use our contact form for the current status of this product. We will work directly with you to ensure your needs are met.
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