5′ AMP-activated protein kinase (AMPK is a heterotrimeric kinase which is critical for regulation of energy homeostasis.
This enzyme is homologous to Rat AMPK (Alpha-1, Beta-1, Gamma-1).
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PERK also commonly known as EIF2AK3, is a key enzyme in the development and function of the insulin secreting beta cells. Mutations in PERK are known to cause the genetic disorder Wolcott Rallison syndrome, neonatal diabetes, exocrine pancreas deficiency, growth retardation, hepatic dysfunctions and skeletal dysplasia.
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