The receptor tyrosine kinase (RTK) family of proteins is responsible for sensing the presence of extracellular hormones, cytokines and growth factors through a cell-surface localized receptor domain, and transducing a signal through an intracellular tyrosine kinase domain to elicit cellular responses. Certain disease states, such as transformed growth (cancer) and insulin-insensitivity (diabetes, obesity), arise when RTK signaling becomes dysregulated or inactivated, making this family important targets in drug discovery.
The insulin-like growth factor I receptor (IGF1R) has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. IGF1R plays a critical role in transformation events. IGF1R is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. This protein is His-tagged.
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The insulin-like growth factor I receptor (IGF1R) has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. IGF1R plays a critical role in transformation events. IGF1R is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. This protein is tandem tagged and includes our proprietary biotinylation motif, the Puritin™ tag, suitable for binding to streptavidin matrices.
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of receptor tyrosine kinases. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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