Gene Synthesis emerged as a more rapid and dynamic alternative tool for genetic manipulation by the beginning of the millennium and has become a vital part of Blue Sky’s service pipeline. Gene Synthesis is the in vitro process of taking single nucleotide building blocks or small oligonucleotides and systematically assembling them into a gene of defined sequence. Blue Sky developed its own methods in 2004 to meet emerging market needs and continues to improve the Chain Blue Lightning process.

1. Unlike traditional cloning, one can engineer a gene so it is tailored to the host organism, such as taking a human gene and tailoring it to bacterial preferences, thus allowing the gene to be expressed in greater abundance and perhaps a more conducive protein form for downstream study.
2. A scientist can plan a modular strategy for gene construction from pieces to final full-length gene (from blocks to the final structure), whereas with traditional cloning the plan is reversed and more cumbersome (using final structures, deconstructing to new blocks, reconstructing blocks into final structures).
3. It is often faster.
4. It is usually more economical.